This is from Yahoo Answers:
Is the foreskin really self-cleaning?
I read that people say before that it’s self-cleaning. Is that really true? It says online that it has many immunological functions. Others say that it’s not self-cleaning and that you have to wash every day.
Best Answer: Merlin gave a good response. For the most part, the foreskin cleans itself during urination, however as you age, it is always a good idea to take the three seconds in the shower to retract and rinse it each day.
Up till puberty, the foreskin and glans are fused together by connective tissue called Synehcia. This seals the area under the foreskin, keeping out dirt, and bacteria. If the foreskin was not self cleaning to some extent, it would collect the variety of dead skin cells, urine deposits, and seminal secretions that happen each day,….
Women produce on the order of five time the amount of vaginal secretions than men produce, and they are expected to take the time to ensure their genitals are kept clean. It takes far less effort for a man to retract his foreskin and rinse it under the shower, than it takes a women to clean in the vaginal folds.
The foreskin/glans combination produce a powerful anti mmicrobialcompound called Langerin. Langerin wards off bacteria, and keeps this area clean, and disease free. Circumcised men miss out on all this life long protection.
Go to: http://www.norm.org and read about the reason and function of the foreskin. You will see how much better off intact men are than circumcised men.
Good luck and I hope this helps.
On Pub Med
Langerin is a natural barrier to HIV-1 transmission by Langerhans cells.
Circumcision May Actually Increase the Risk of HIV:
Researchers has discovered that the foreskin may actually protect the body from infection by HIV.
The inner foreskin of uncircumcised men has Langerhans cells, which produce a protein called Langerin. When HIV tries to attack, Langerin “eats up” the virus before it can attack the host.
When the foreskin is removed, the penis is left defenseless without Langerin, making it even easier for HIV to infect the immune system.